Activation of energy expenditure in the rat by a new non-amphetaminic compound: the (4-chlorophenoxyacetate) N-methyl 3-hydroxymethyl piperidine, hydrochloride (PM 170).
PMID 3841663 · International journal of obesity · 1985
Authors: F Massicot; D Ricquier; J J Godfroid; M Apfelbaum
Abstract
The (4-chlorophenoxyacetate) N-methyl 3-hydroxymethyl piperidine, hydrochloride (PM 170), chemically unrelated to amphetamine, was studied in normal rats for any thermogenic effect. It was given in graded doses. After an acute treatment PM 170 increases energy expenditure by increasing resting oxygen consumption (VO2) and in the doses used, produced dose-related increases in VO2. Energy expenditure of rats treated for 16 days was chronically elevated, while body weight gain and food intake were reduced. It also stimulated mitochondrial oxygen consumption probably by partial uncoupling of respiration from ATP synthesis. The disruption of oxidative phosphorylation could partially explain the effect of this compound on resting metabolic rate.
Animals; Body Temperature Regulation; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Injections, Intraperitoneal; Male; Mitochondria, Liver; Obesity; Oxygen Consumption; Piperidines; Rats; Rats, Inbred Strains; Time Factors
Cite
F Massicot; D Ricquier; J J Godfroid; M Apfelbaum. Activation of energy expenditure in the rat by a new non-amphetaminic compound: the (4-chlorophenoxyacetate) N-methyl 3-hydroxymethyl piperidine, hydrochloride (PM 170). International journal of obesity (1985). PMID 3841663.