Granulomatous mastitis caused by Rickettsia species.
PMID 33851237 · Virchows Archiv : an international journal of pathology · 2021 · DOI 10.1111/j.1600-0463.2009.02435.x
Authors: Annette Bauer; Syster Hofmeyer; Maria Gere; Kenneth Nilsson; Tibor Tot
Abstract
Granulomatous mastitis is a rare inflammatory disease of varying etiology. Tuberculosis and cystic neutrophilic granulomatous mastitis caused by Corynebacterium are the best-established infectious examples. Despite the increasing incidence of Rickettsia-related diseases worldwide, granulomatous inflammation of breast parenchyma caused by Rickettsia has not yet been reported. We present a unique case of bilateral granulomatous mastitis documented with mammography, magnetic resonance imaging and core-needle biopsy. The rickettsial etiology of the disease was proved with specific immunohistochemistry and confirmed with DNA extraction, PCR and serology. The lesions completely resolved after a full-course tetracycline treatment. This case report widens the knowledge about the possible clinical manifestations of Rickettsia infection and adds a new bacterium to the list of etiological factors causing granulomatous mastitis.
Anti-Bacterial Agents; Bacteriological Techniques; Biopsy, Large-Core Needle; Female; Granulomatous Mastitis; Humans; Magnetic Resonance Imaging; Mammography; Middle Aged; Rickettsia; Rickettsia Infections; Tetracycline; Treatment Outcome
Cite
Annette Bauer; Syster Hofmeyer; Maria Gere; Kenneth Nilsson; Tibor Tot. Granulomatous mastitis caused by Rickettsia species. Virchows Archiv : an international journal of pathology (2021). PMID 33851237. DOI 10.1111/j.1600-0463.2009.02435.x.