Methicillin-susceptible staphylococcus aureus in community-acquired pneumonia: Risk factors and outcomes.
PMID 33144192 · The Journal of infection · 2021 · DOI 10.1016/j.jinf.2020.10.032
Authors: Catia Cilloniz; Cristina Dominedò; Albert Gabarrús; Carolina Garcia-Vidal; José Becerril; Diego Tovar; Estela Moreno; Juan M Pericás; Carmen Rosa Vargas; Antoni Torres
Abstract
We aimed to describe the prevalence, risk factors and outcomes of Methicillin-susceptible S. aureus (MSSA) community-acquired pneumonia (CAP) and compare them with those associated with CAP due to Streptococcus pneumoniae, the most frequent causative microorganism, in a large cohort of patients. This was an observational study of prospectively collected data of consecutive adults with CAP and a definitive etiology enrolled between 2004 and 2018. Patients were divided into MSSA CAP and pneumococcal CAP groups for analysis. A microbial etiology was established in 1,548 (33%) cases: S. aureus caused 6% of microbiologically-confirmed CAP cases. In the latter, 52 were due to MSSA (60% of S. aureus CAP cases, and 3% of microbiologically-confirmed CAP cases) and 34 were due to MRSA (40% of S. aureus CAP cases, and 2% of microbiologically-confirmed CAP cases). S. pneumoniae was identified in 734 (47%) microbiologically-confirmed CAP cases. The presence of fever was independently associated with a lower risk of MSSA CAP (OR 0.53; 95% CI, 0.28-0.99). Patients with MSSA CAP had higher 30-day mortality than patients with pneumococcal CAP, both before and after adjustment for potential confounders (21% vs 7%, p = 0.002). MSSA was independently associated with 30-day mortality in the overall population. MSSA CAP was associated with worse outcomes than pneumococcal CAP in our cohort. MSSA was an independent factor of mortality.
Adult; Community-Acquired Infections; Humans; Methicillin; Methicillin-Resistant Staphylococcus aureus; Pneumonia; Risk Factors; Staphylococcal Infections; Staphylococcus aureus
Cite
Catia Cilloniz; Cristina Dominedò; Albert Gabarrús; Carolina Garcia-Vidal; José Becerril; Diego Tovar; Estela Moreno; Juan M Pericás; Carmen Rosa Vargas; Antoni Torres. Methicillin-susceptible staphylococcus aureus in community-acquired pneumonia: Risk factors and outcomes. The Journal of infection (2021). PMID 33144192. DOI 10.1016/j.jinf.2020.10.032.