Role of Leptin in Mood Disorder and Neurodegenerative Disease.
PMID 31130833 · Frontiers in neuroscience · 2019 · DOI 10.3389/fnins.2019.00378
Authors: Xiaohan Zou; Lili Zhong; Cuilin Zhu; Haisheng Zhao; Fangyi Zhao; Ranji Cui; Shuohui Gao; Bingjin Li
Abstract
The critical regulatory role of leptin in the neuroendocrine system has been widely reported. Significantly, leptin can improve learning and memory, affect hippocampal synaptic plasticity, exert neuroprotective efficacy and reduce the risk of several neuropsychiatric diseases. In terms of depression, leptin could modulate the levels of neurotransmitters, neurotrophic factors and reverse the dysfunction in the hypothalamic-pituitary-adrenal axis (HPA). At the same time, leptin affects neurological diseases during the regulation of metabolic homeostasis. With regards to neurodegenerative diseases, leptin can affect them via neuroprotection, mainly including Alzheimer's disease and Parkinson's disease. This review will summarize the mechanisms of leptin signaling within the neuroendocrine system with respect to these diseases and discuss the therapeutic potential of leptin.
Cite
Xiaohan Zou; Lili Zhong; Cuilin Zhu; Haisheng Zhao; Fangyi Zhao; Ranji Cui; Shuohui Gao; Bingjin Li. Role of Leptin in Mood Disorder and Neurodegenerative Disease. Frontiers in neuroscience (2019). PMID 31130833. DOI 10.3389/fnins.2019.00378.