Metabolome Wide Association Study of Serum Poly and Perfluoroalkyl Substances (PFASs) in Pregnancy and Early Postpartum.
PMID 31121237 · Reproductive toxicology (Elmsford, N.Y.) · 2019 · DOI 10.1016/j.reprotox.2019.05.058
Authors: Xin Hu; Shuzhao Li; Piera M Cirillo; Nickilou Y Krigbaum; ViLinh Tran; Dean P Jones; Barbara A Cohn
Abstract
High-resolution metabolomics (HRM) profiling of metabolic fingerprints can improve understanding of how poly and perfluoroalkyl substances (PFASs) induce metabolic alterations of in utero environment and impact fetal health. HRM profiling and quantification of PFASs were performed for 397 maternal perinatal serum samples collected from 1959-1967 in the Child Health and Development Studies (CHDS). We used Metabolome-Wide Association Studies (MWAS) and pathway enrichment analysis for metabolic associations with PFOS, its precursor EtFOSAA, and EtFOSAA-to-PFOS ratio. Distinct metabolic profiles were found with EtFOSAA and PFOS. Urea cycle metabolites such as arginine, lysine and creatine had opposite associations with EtFOSAA (negative) and PFOS (positive); whereas, carnitine shuttle metabolites were found to be exclusively and positively associated with PFOS indicating perturbation in fatty acid metabolism. These differential metabolic associations for precursor and end-product represent an important first step in identifying how PFASs alter the in utero environment and potentially leads to disease risk.
Adult; Alkanesulfonic Acids; Biological Monitoring; Female; Fluorocarbons; Humans; Metabolome; Postpartum Period; Pregnancy; Young Adult
Cite
Xin Hu; Shuzhao Li; Piera M Cirillo; Nickilou Y Krigbaum; ViLinh Tran; Dean P Jones; Barbara A Cohn. Metabolome Wide Association Study of Serum Poly and Perfluoroalkyl Substances (PFASs) in Pregnancy and Early Postpartum. Reproductive toxicology (Elmsford, N.Y.) (2019). PMID 31121237. DOI 10.1016/j.reprotox.2019.05.058.