Tyrosine hydroxylase activity in brain regions after intraventricular 6-hydroxydopamine in the neonatal rat.
PMID 28554 · Research communications in chemical pathology and pharmacology · 1978
Authors: D A Peters; B A Pappas; H Taub; M Saari
Abstract
Intraventricular 6-OHDA treatment to newborn rats produced a marked reduction in tyrosine hydroxylase activity in most brain regions at maturity which correlated moderately well with the catecholamine levels. However, those regions in which NE levels were increased did not show a corresponding increase in total tyrosine hydroxylase activity. There was a much better correlation between NE levels and the particulate form of tyrosine hydroxylase which has been suggested to be the more functionally active form of the enzyme.
Animals; Animals, Newborn; Brain; Cerebellum; Hydroxydopamines; Injections, Intraventricular; Pons; Rats; Tyrosine 3-Monooxygenase
Cite
D A Peters; B A Pappas; H Taub; M Saari. Tyrosine hydroxylase activity in brain regions after intraventricular 6-hydroxydopamine in the neonatal rat. Research communications in chemical pathology and pharmacology (1978). PMID 28554.