Temperature-driven switching of the catalytic activity of artificial glutathione peroxidase by the shape transition between the nanotubes and vesicle-like structures.
PMID 24654792 · Langmuir : the ACS journal of surfaces and colloids · 2014 · DOI 10.1021/la5008236
Authors: Liang Wang; Huixin Zou; Zeyuan Dong; Lipeng Zhou; Jiaxi Li; Quan Luo; Junyan Zhu; Jiayun Xu; Junqiu Liu
Abstract
Smart supramolecular nanoenzymes with temperature-driven switching property have been successfully constructed by the self-assembly of supra-amphiphiles formed by the cyclodextrin-based host-guest chemistry. The self-assembled nanostructures were catalyst-functionalized and thermosensitively-functionalized through conveniently linking the catalytic center of glutathione peroxidase and thermosensitive polymer to the host cyclodextrin molecules.The ON-OFF switches for the peroxidase activity by reversible transformation of nanostructures from tube to sphere have been achieved through changing the temperature. We anticipate that such intelligent enzyme mimics could be developed to use in an antioxidant medicine with controlled catalytic efficiency according to the needs of the human body in the future.
Acrylic Resins; Biocatalysis; Cyclodextrins; Glutathione Peroxidase; Nanotubes; Particle Size; Phase Transition; Surface Properties; Temperature
Cite
Liang Wang; Huixin Zou; Zeyuan Dong; Lipeng Zhou; Jiaxi Li; Quan Luo; Junyan Zhu; Jiayun Xu; Junqiu Liu. Temperature-driven switching of the catalytic activity of artificial glutathione peroxidase by the shape transition between the nanotubes and vesicle-like structures. Langmuir : the ACS journal of surfaces and colloids (2014). PMID 24654792. DOI 10.1021/la5008236.