Resources for functional genomics studies in Drosophila melanogaster.
PMID 24653003 · Genetics · 2014 · DOI 10.1534/genetics.113.154344
Authors: Stephanie E Mohr; Yanhui Hu; Kevin Kim; Benjamin E Housden; Norbert Perrimon
Abstract
Drosophila melanogaster has become a system of choice for functional genomic studies. Many resources, including online databases and software tools, are now available to support design or identification of relevant fly stocks and reagents or analysis and mining of existing functional genomic, transcriptomic, proteomic, etc. datasets. These include large community collections of fly stocks and plasmid clones, "meta" information sites like FlyBase and FlyMine, and an increasing number of more specialized reagents, databases, and online tools. Here, we introduce key resources useful to plan large-scale functional genomics studies in Drosophila and to analyze, integrate, and mine the results of those studies in ways that facilitate identification of highest-confidence results and generation of new hypotheses. We also discuss ways in which existing resources can be used and might be improved and suggest a few areas of future development that would further support large- and small-scale studies in Drosophila and facilitate use of Drosophila information by the research community more generally.
Animals; Databases, Genetic; Drosophila melanogaster; Genetic Engineering; Genome, Insect; Genomics; Humans
Cite
Stephanie E Mohr; Yanhui Hu; Kevin Kim; Benjamin E Housden; Norbert Perrimon. Resources for functional genomics studies in Drosophila melanogaster. Genetics (2014). PMID 24653003. DOI 10.1534/genetics.113.154344.