Alterations in tyrosine aminotransferase isoenzymes of liver of rats as a function of age.
PMID 21998 · Mechanisms of ageing and development · 1977 · DOI 10.1016/0047-6374(77)90044-6
Authors: B K Ratha; M S Kanungo
Abstract
The specific activities (units/mg protein) of tyrosine aminotransferase (TAT) and its isoenzymes, cytoplasmic (c-), mitochondrial (m-) and nuclear (n-TAT), of the liver of 6-, 35- and 76-week old male albino rats were determined. The activities of all the isoenzymes are highest at 6 weeks and are significantly lower at 35 weeks. Total TAT and c-TAT remain unchanged, m-TAT decreases and n-TAT increases significantly after 35 weeks. c-TAT was partially purified from the liver of rats of the three ages to study its kinetic and molecular properties. These properties apparently do not change as a function of age.
Age Factors; Animals; Cell Nucleus; Cytoplasm; Glutamates; Isoenzymes; Ketoglutaric Acids; Kinetics; Liver; Male; Mitochondria, Liver; Rats; Tyrosine; Tyrosine Transaminase
Cite
B K Ratha; M S Kanungo. Alterations in tyrosine aminotransferase isoenzymes of liver of rats as a function of age. Mechanisms of ageing and development (1977). PMID 21998. DOI 10.1016/0047-6374(77)90044-6.