-383 A/C tumor necrosis factor receptor 1 polymorphism and ankylosing spondylitis in Mexicans: a preliminary study.
PMID 21789618 · Rheumatology international · 2012 · DOI 10.1007/s00296-011-1997-5
Authors: Esther Guadalupe Corona-Sanchez; José Francisco Muñoz-Valle; Laura Gonzalez-Lopez; Julia Dolores Sanchez-Hernandez; Monica Vazquez-Del Mercado; Heriberto Ontiveros-Mercado; Miguel Huerta; Xochitl Trujillo; Alberto Daniel Rocha-Muñoz; Alfredo Celis; Ricardo Ortega-Flores; Jorge Ivan Gamez-Nava
Abstract
The objective of this study was to evaluate the differences in allele and genotype frequencies of -383 tumor necrosis factor receptor 1 (TNFR1) polymorphism between ankylosing spondylitis (AS) and controls. Mexican Mestizos with AS were matched by gender, age, and ethnicity with healthy controls and compared in allele and genotype frequencies of the -383 TNFR1 polymorphism. Polymorphisms were genotyped using PCR-RFLP. The AA genotype occurred at a higher frequency in the AS group (92%) compared with controls (79%, P = 0.03). A allele was increased in AS (96% vs. 88%, P = 0.015) and was associated with genetic susceptibility for AS (odds ratio = 3.48, 95% CI = 1.23-10.61). This preliminary study is the first assessing the association of the -383 A/C TNFR1 polymorphism with AS, although it has the limitation of a small sample size. These data are of interest for the genetic epidemiology of AS in the Mexican population, requiring further investigation in other countries.
Adult; Case-Control Studies; Chi-Square Distribution; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Mexico; Middle Aged; Odds Ratio; Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Promoter Regions, Genetic; Receptors, Tumor Necrosis Factor, Type I; Risk Assessment; Risk Factors; Severity of Illness Index; Spondylitis, Ankylosing
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Esther Guadalupe Corona-Sanchez; José Francisco Muñoz-Valle; Laura Gonzalez-Lopez; Julia Dolores Sanchez-Hernandez; Monica Vazquez-Del Mercado; Heriberto Ontiveros-Mercado; Miguel Huerta; Xochitl Trujillo; Alberto Daniel Rocha-Muñoz; Alfredo Celis; Ricardo Ortega-Flores; Jorge Ivan Gamez-Nava. -383 A/C tumor necrosis factor receptor 1 polymorphism and ankylosing spondylitis in Mexicans: a preliminary study. Rheumatology international (2012). PMID 21789618. DOI 10.1007/s00296-011-1997-5.