Toxicokinetics of pyrethroid metabolites in male and female rats.
PMID 21787635 · Environmental toxicology and pharmacology · 2010 · DOI 10.1016/j.etap.2010.03.017
Authors: Jun Ueyama; Naoko Hirosawa; Aiko Mochizuki; Akiko Kimata; Michihiro Kamijima; Takaaki Kondo; Kenji Takagi; Shinya Wakusawa; Takaaki Hasegawa
Abstract
The toxicokinetic characteristics of 3-phenoxybenzyl alcohol (3PBAlc) and 3-phenoxybenzaldehyde (3PBAld; metabolites of pyrethroid [PYR] after 25mg/kg, single intravenous administration), were investigated in male and female rats. The systemic clearance (Cl) of 3PBAlc in females (0.403±0.040l/h/kg) was significantly larger than that of males (0.227±0.036l/h/kg). The plasma concentration-time curve of 3PBAld decreased gradually and then increased again 1 and 2h after injection, suggesting the effect of enterohepatic circulation. The present study characterized the elimination and distribution of PYR metabolites and suggests that gender-related difference exists in the toxicokinetics of 3PBAlc and 3PBAld in rats.
Cite
Jun Ueyama; Naoko Hirosawa; Aiko Mochizuki; Akiko Kimata; Michihiro Kamijima; Takaaki Kondo; Kenji Takagi; Shinya Wakusawa; Takaaki Hasegawa. Toxicokinetics of pyrethroid metabolites in male and female rats. Environmental toxicology and pharmacology (2010). PMID 21787635. DOI 10.1016/j.etap.2010.03.017.