The effect of the reciprocal relationship of Ca2+ and cAMP on the control of beating in cultured rat heart cells.
PMID 202002 · Recent advances in studies on cardiac structure and metabolism · 1976
Authors: I Harary; G A Wallace
Abstract
The demonstration of Ca2+ control of the cAMP level in heart cells and the localization of the Ca2+ activator protein of cAMP phosphodiesterase on the sarcoplasmic reticulum (SR) have led us to postulate a model whereby the Ca2+ flux is related to the cAMP flux. The model suggests that the increase in cytosol Ca2+ automatically results in an increase in SR Ca2+ and a subsequent decrease in cAMP to allow for the periodic flux of Ca2+ and cAMP in the contraction cycle.
3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium; Culture Techniques; Cyclic AMP; Heart; Kinetics; Models, Biological; Muscle Proteins; Myocardial Contraction; Myocardium; Rats; Sarcoplasmic Reticulum
Cite
I Harary; G A Wallace. The effect of the reciprocal relationship of Ca2+ and cAMP on the control of beating in cultured rat heart cells. Recent advances in studies on cardiac structure and metabolism (1976). PMID 202002.