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Nucleotide sequence of the DNA encoding the 5'-terminal sequences of simian virus 40 late mRNA.

PMID 201640 · The Journal of biological chemistry · 1978

Authors: R Dhar; V B Reddy; S M Weissman

Abstract

We have used a combination of techniques of DNA and RNA sequence analysis to determine the nucleotide sequence of the portion of simian virus 40 DNA preceding and encoding the 5' end of mRNA for the structural protein VP2 of simian virus 40. Comparison of the sequence with those found in polyadenylated RNA in the cytoplasm of infected cells RNA shows that the transcript of sequences preceding the structural gene is more abundant than the transcript containing the codons for the protein. Between the abundant transcript of sequences preceding the coding region and the less abundant transcript of the coding region there is a short sequence whose transcript is not detected.

Base Sequence; DNA, Viral; Oligoribonucleotides; Phosphoric Diester Hydrolases; RNA, Messenger; Ribonuclease T1; Simian virus 40

PubMed record

Cite

R Dhar; V B Reddy; S M Weissman. Nucleotide sequence of the DNA encoding the 5'-terminal sequences of simian virus 40 late mRNA. The Journal of biological chemistry (1978). PMID 201640.