Effect of phosgene on rat lungs after single high-level exposure.
PMID 201220 · Archives of environmental health · 1977 · DOI 10.1080/00039896.1977.10667294
Authors: M F Frosolono; R Pawlowski
Abstract
Rats were exposed under static conditions to phosgene at concentrations within the LCt50 range and above. Lungs were removed at various postexposure intervals. Degrees of pulmonary edema were estimated by increases in percentage of water in the lungs of exposed groups as opposed to control animals. Lungs were fractionated into four major subcellular organelle fractions: nuclear debris, mitochondrial-lysosomal, microsomal, and soluble (cytoplasmic). Activities of p-nitrophenyl phosphatase, cytochrome C oxidase, ATP'ase, and LDH within these fractions were decreased after phosgene exposure. There was a concomitant increase in serum LDH levels. One possible mechanism that may play a role in phosgene damage can be associated with either inhibition or loss of enzyme activities from the lung.
4-Nitrophenylphosphatase; Adenosine Triphosphatases; Animals; Atmosphere Exposure Chambers; Electron Transport Complex IV; L-Lactate Dehydrogenase; Lung; Male; Phosgene; Pulmonary Edema; Rats
Cite
M F Frosolono; R Pawlowski. Effect of phosgene on rat lungs after single high-level exposure. Archives of environmental health (1977). PMID 201220. DOI 10.1080/00039896.1977.10667294.