Polymyxin B and rifampin: new regimen for multiresistant Serratia marcescens infections.
PMID 201214 · Antimicrobial agents and chemotherapy · 1977 · DOI 10.1128/AAC.12.6.655
Authors: R C Ostenson; B T Fields; C M Nolan
Abstract
Polymyxin B and rifampin were given to 12 patients with multi-drug-resistant nosocomial Serratia marcescens infections. Eight cures were achieved; drug hepatotoxicity occurred once; one fatal suprainfection was encountered; and two patients died during therapy of causes related to severe underlying illnesses. Polymyxin B and rifampin were uniformly synergistic in vitro against the infecting strains and against 40 additional clinical isolates of S. marcescens.
Adult; Aged; Drug Resistance, Microbial; Enterobacteriaceae Infections; Female; Humans; Male; Middle Aged; Polymyxin B; Polymyxins; Rifampin; Serratia marcescens
Cite
R C Ostenson; B T Fields; C M Nolan. Polymyxin B and rifampin: new regimen for multiresistant Serratia marcescens infections. Antimicrobial agents and chemotherapy (1977). PMID 201214. DOI 10.1128/AAC.12.6.655.