Effect of adenosine compounds (ATP, cAMP) on renin release in vitro.
PMID 200064 · Acta physiologica Academiae Scientiarum Hungaricae · 1976
Authors: K Gaál; I Forgács; Z Bácsalmásy
Abstract
Renin release by surviving canine renal cortical slices incubated media with ATP or cAMP at concentrations of 5 X 10(-5)--5 X 10(-3) M has been studied. Both adenosine compounds were significantly increasing renin release. A linear correlation was observed between their dose and the renin activity of the medium. The difference between the effects of ATP and cAMP appeared to be caused by phosphodiesterase, since the difference was eliminated if to the medium containing cAMP 5 X 10(-2) M theophylline, a phosphodiesterase inhibitor was added.
Adenosine Triphosphate; Animals; Cyclic AMP; Dogs; Female; In Vitro Techniques; Kidney Cortex; Male; Phosphodiesterase Inhibitors; Renin; Theophylline
Cite
K Gaál; I Forgács; Z Bácsalmásy. Effect of adenosine compounds (ATP, cAMP) on renin release in vitro. Acta physiologica Academiae Scientiarum Hungaricae (1976). PMID 200064.