Mechanical and metabolic effects of diazoxide in rat uterus.
PMID 200063 · Acta pharmacologica et toxicologica · 1977 · DOI 10.1111/j.1600-0773.1977.tb02672.x
Authors: S Johansson; R G Andersson; J Wikberg
Abstract
Diazoxide relaxed both polarized and depolarized rat uterus. The drug also conteracted the contractions elicited by Ca2+ in a competitive manner. The relaxing effect was associated with an increase in the tissue level of cyclic AMP. This metabolic effect of diazoxide was inhibited by propranolol-treatment and in preparations from reserpinized animals, while the mechanical effects were only partially reduced. Diazoxide was also found to increase the release of tritium from preparations preloaded with [3H]-noradrenaline. It is suggested that diazoxide may induce some of its mechanical and metabolic effects by releasing the adrenergic transmittor substance noradrenaline. An effect of diazoxide on the Ca2+-metabolism is also probable.
Animals; Calcium; Cyclic AMP; Diazoxide; Electric Stimulation; Female; Muscle Relaxation; Norepinephrine; Phosphoric Diester Hydrolases; Propranolol; Rats; Reserpine; Uterine Contraction; Uterus
Cite
S Johansson; R G Andersson; J Wikberg. Mechanical and metabolic effects of diazoxide in rat uterus. Acta pharmacologica et toxicologica (1977). PMID 200063. DOI 10.1111/j.1600-0773.1977.tb02672.x.