Insulin stimulation tests in pituitary dependent Cushing's syndrome after complete adrenalectomy.
PMID 200044 · Acta endocrinologica · 1977 · DOI 10.1530/acta.0.0860578
Authors: R J Croughs; H Timmermans; A C Vingerhoeds; A Vermeulen; A Smals; P W Kloppenborg; J C Meyer
Abstract
The present study shows that in a group of 6 euadrenal patients, previously treated by complete adrenalectomy for pituitary dependent Cushing's syndrome, the stress stimulus of insulin induced hypoglycaemia is followed by a plasma ACTH response which is of similar magnitude as the response obtained with lysin-vasopressin. Both observations indicate that the central nervous system-pituitary axis is basically normal in pituitary dependent Cushing's syndrome as assessed by insulin induced hypoglycaemia. It is concluded that non-responsiveness of the pituitary-adrenocortical system to insulin induced hypoglycaemia in untreated patients with pituitary dependent Cushing's syndrome does not represent a fundamental defect of the stress mechanism, but is due to hypercorticism per se.
Adrenalectomy; Adrenocorticotropic Hormone; Blood Glucose; Cushing Syndrome; Humans; Insulin; Lypressin
Cite
R J Croughs; H Timmermans; A C Vingerhoeds; A Vermeulen; A Smals; P W Kloppenborg; J C Meyer. Insulin stimulation tests in pituitary dependent Cushing's syndrome after complete adrenalectomy. Acta endocrinologica (1977). PMID 200044. DOI 10.1530/acta.0.0860578.