Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells.
PMID 197319 · Journal of supramolecular structure · 1977 · DOI 10.1002/jss.400060107
Authors: M S Brown; R G Anderson; J L Goldstein
Abstract
Studies comparing the metabolism of low density lipoprotein (LDL) in normal cells and in cells cultured from patients with homozygous familial hypercholesterolemia have disclosed the existence of a receptor for plasma LDL. This receptor has been identified on the surface of human fibroblasts, lymphocytes, and aortic smooth muscle cells. An extension of these studies to cell strains derived from patients with other single gene defects in cholesterol metabolism has provided additional insight into the normal mechanisms by which cells regulate their cholesterol content and how alterations in these genetic control mechanisms may predispose to atherosclerosis in man.
Aorta; Cells, Cultured; Cholesterol Esters; Fibroblasts; Humans; Hypercholesterolemia; Lipoproteins, HDL; Lipoproteins, LDL; Lymphocytes; Lysosomes; Muscle, Smooth; Mutation; Oleic Acids; Receptors, Drug
Cite
M S Brown; R G Anderson; J L Goldstein. Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells. Journal of supramolecular structure (1977). PMID 197319. DOI 10.1002/jss.400060107.