Dexamethasone suppression of ovulation in PMS-treated immature rats.
PMID 192574 · Experientia · 1977 · DOI 10.1007/BF02002851
Authors: K F Soliman; C A Walker
Abstract
A single injection of 2.0 mg/kg dexamethasone (DXM) administered at 51 h after pregnant mare serum gonadatropin (PMS) treatment inhibited both ovulation and luteinization. S.c. injection of human chorionic gonadotropin (HGG) caused ovulation and luteinization in DXM-PMS-treated rats, whereas treatment with ACTH failed to overcome the DXM inhibitory effect. These findings are interpreted to indicate that DXM inhibits ovulation through a mechanism which might involve the central nervous system.
Adrenocorticotropic Hormone; Animals; Body Weight; Chorionic Gonadotropin; Dexamethasone; Female; Gonadotropins, Equine; Organ Size; Ovary; Ovulation; Rats; Uterus
Cite
K F Soliman; C A Walker. Dexamethasone suppression of ovulation in PMS-treated immature rats. Experientia (1977). PMID 192574. DOI 10.1007/BF02002851.