Prostaglandin E2 production in 3T3 cells transformed by polyoma virus raises the intracellular adenosine 3':5'-monophosphate levels.
PMID 192547 · European journal of biochemistry · 1977 · DOI 10.1111/j.1432-1033.1977.tb11361.x
Authors: H E Claesson; J A Lindgren; S Hammarström
Abstract
High cellular adenosine 3':5'-monophosphate (cyclic AMP) were found in a polyoma-virus-transformed 3T3 fibroblast line, which produces comparatively high prostaglandin E2 concentrations. Prostaglandin E2 and cyclic AMP increased with time during 6 days of growth. Both effects were prevented by three different cyclo-oxygenase inhibitors. Addition of prostaglandin E2, at a concentration which would been synthesized in the absence of inhibitor, reversed the effect of indomethacin, one of the cyclo-oxygenase inhibitors, on cyclic AMP. It is concluded that endogenous prostaglandin E2 production in these transformed cells influences their cellular cyclic AMP levels.
5,8,11,14-Eicosatetraynoic Acid; Aspirin; Cell Line; Cell Transformation, Neoplastic; Cyclic AMP; Indomethacin; Kinetics; Polyomavirus; Prostaglandins E
Cite
H E Claesson; J A Lindgren; S Hammarström. Prostaglandin E2 production in 3T3 cells transformed by polyoma virus raises the intracellular adenosine 3':5'-monophosphate levels. European journal of biochemistry (1977). PMID 192547. DOI 10.1111/j.1432-1033.1977.tb11361.x.