Selective hypoaldosteronism: a study of steroid biosynthetic pathways under adrenocorticotrophin and angiotensin II infusion.
PMID 192516 · Clinical science and molecular medicine. Supplement · 1976 · DOI 10.1042/cs051335s
Authors: M Lebel; J H Grose
Abstract
1. The functional integrity of the adrenal cortex has been tested in a case of selective hypoaldosteronism by adrenocorticotrophin (ACTH) and angiotensin II (AII) infusion. 2. During ACTH infusion a normal functioning zona fasciculata was indicated by the impressive increase of the ACTH-dependent plasma steroids; the aldosterone response was moderate. 3. During AII infusion the plasma aldosterone response was blunted with an unexpected dose-dependent increase in pregnenolone, resulting in abnormal decreasing progesterone/pregnenolone ratios during the infusion, suggesting a slow-down in the conversion of pregnenolone into progesterone. 4. This defect, a probable consequence of chronic renin deficiency on the zona glomerulosa, could be a contributing factor to the hypoaldosteronism.
Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Female; Humans; Hydroxycorticosteroids; Middle Aged; Progestins; Stimulation, Chemical
Cite
M Lebel; J H Grose. Selective hypoaldosteronism: a study of steroid biosynthetic pathways under adrenocorticotrophin and angiotensin II infusion. Clinical science and molecular medicine. Supplement (1976). PMID 192516. DOI 10.1042/cs051335s.