Further unravelling of the causes of ACTH-induced hypertension in the sheep.
PMID 192514 · Clinical science and molecular medicine. Supplement · 1976 · DOI 10.1042/cs051295s
Authors: J P Coghlan; D A Denton; J S Fan; J G McDoughall; B A Scoggins; A A Shulkes
Abstract
1. Acute severe sodium subtraction (20-25% of total exchangeable sodium) before or during treatment with adrenocorticotrophic hormone (ACTH) does little to modify the increase in blood pressure induced by ACTH. 2. Chronic low salt diet, less than 5 mmol/day, abolishes the blood pressure increase, but the response can be restored by increasing the sodium intake to as little as 10 mmol/day. 3. 17alpha,20alpha-Dihydroxyprogesterone infused concurrently with other adrenal steroids will mimic ACTH hypertension and perhaps represents a new class of steroid capable of influencing blood pressure.
Adrenocorticotropic Hormone; Algestone; Animals; Hydroxyprogesterones; Hypertension; Sheep; Sodium
Cite
J P Coghlan; D A Denton; J S Fan; J G McDoughall; B A Scoggins; A A Shulkes. Further unravelling of the causes of ACTH-induced hypertension in the sheep. Clinical science and molecular medicine. Supplement (1976). PMID 192514. DOI 10.1042/cs051295s.