Functional-morphological correlates of renomedullary interstitial cells.
PMID 192513 · Clinical science and molecular medicine. Supplement · 1976 · DOI 10.1042/cs051291s
Authors: J A Pitcock; W A Rightsel; P Brown; B Brooks; E E Muirhead
Abstract
1. Indomethacin treatment of renomedullary interstitial cells (RIC) causes a marked increase in number and size of their lipid droplets. The anti-hypertensive function is retained. 2. After multiple passages in tissue culture, RIC lose their ability to produce an anti-hypertensive effect in hypertensive animals. Along with this functional loss, lipid droplets and a prominent cisternal system become attenuated or disappear. 3. We conclude that preservation of the lipid granule-cisternal organelle relationship is important in preservation of the anti-hypertensive endocrine function of RIC.
Antihypertensive Agents; Inclusion Bodies; Indomethacin; Kidney; Kidney Medulla; Lipid Metabolism; Microscopy, Electron
Cite
J A Pitcock; W A Rightsel; P Brown; B Brooks; E E Muirhead. Functional-morphological correlates of renomedullary interstitial cells. Clinical science and molecular medicine. Supplement (1976). PMID 192513. DOI 10.1042/cs051291s.