Prostaglandins in adrenergic transmission of isolated perfused rat pancreas.
PMID 190895 · The American journal of physiology · 1977 · DOI 10.1152/ajpendo.1977.232.2.E201
Authors: M Hamamdzić; K U Malik
Abstract
In the isolated, perfused rat pancreas, prostaglandins (PGs) E1 and E2 1-5 ng/ml, reduced the vasoconstrictor responses to periarterial nerve stimulation and variably affected those to injected norepinephrine. Prostaglandin F2alpha had no consistent effect on the vasoconstrictor responses to both adrenergic stimuli. Stimulation of adrenergic nerves or administration of norepinephrine released a PGE-like substance from the perfused pancreas which was abolished by inhibitors of PG synthesis, acetylsalicylic acid, indomethacin, meclofenamate, and eicosa-5,8,11,14-tetraynoic acid. The latter three agents did not potentiate, but rather reduced the vasoconstrictor responses to both adrenergic stimuli. Arachidonic acid that was converted by the pancreas into PGE2 and PGF2alpha inhibited the vasoconstrictor responses to adrenergic stimuli. The latter effect of arachidonic acid was not altered by the simultaneous infusion of PG synthetase inhibitors. Although these results, which could be attributed to a direct effect of inhibitors of PG synthesis and arachidonic acid on adrenergic neuroeffector junction, fail to establish the role of endogenous PGs in modulating adrenergic responses in rat pancreatic vessels, they emphasize the differences in the effect of PGE1 and PGE2 on adrenergic responses in various vascular beds of the rat.
5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Arteries; Aspirin; Electric Stimulation; Indomethacin; Male; Meclofenamic Acid; Norepinephrine; Pancreas; Perfusion; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Sympathetic Nervous System; Synaptic Transmission; Vasomotor System
Cite
M Hamamdzić; K U Malik. Prostaglandins in adrenergic transmission of isolated perfused rat pancreas. The American journal of physiology (1977). PMID 190895. DOI 10.1152/ajpendo.1977.232.2.E201.