The value of urinary steroid analysis in chorionic neoplasia.
PMID 190888 · American journal of obstetrics and gynecology · 1977 · DOI 10.1016/0002-9378(77)90364-7
Authors: M Kodama; R Totani; T Kodama
Abstract
The profile of urinary neutral steroids was investigated in normal pregnancy and chorionic neoplasia by gas-liquid chromatography. The whole chramatogram was divided into three metabolically distinct fractions. The excretion of fraction 2, including four menstruation-dependent steroids (11-hydroxyandrosterone, 11-hydroxyetiocholanolone, pregnanediol, and pregnanetrial), was remarkably increased in normal pregnancy as compared with that in nonpregnant controls. But the same parameter was differentially reduced in hydatidiform mole (HM) and chorioadenoma destruens (CA) as compared with normal pregnancy, and the ratio of fraction 2 to fraction 1 (11-deoxy-17-ketosteroids) was found useful in separating normal pregnancy, HM, and CA from each other. In choriocarcinoma (CC), reduced excretion was observed in both fraction 1 and fraction 2 steroids. The linear relationship between the logarithm of fraction 2-fraction 1 ratio and that of pregnanediol excretion, as observed in the reproductive cycle of a healthy woman, was not detectable in women with CA, whose urine revealed a low value of log (fraction 2/fraction 1) in spite of an abundant HCG content. It is indicated that the above findings reflect the deficiency of ovarian steroidogenesis under the influence of abnormal HCG from tumors.
Adrenal Cortex Hormones; Choriocarcinoma; Chorionic Gonadotropin; Female; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Mathematics; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms
Cite
M Kodama; R Totani; T Kodama. The value of urinary steroid analysis in chorionic neoplasia. American journal of obstetrics and gynecology (1977). PMID 190888. DOI 10.1016/0002-9378(77)90364-7.