Conjugated catechol derivatives in a transplantable islet cell tumour of the golden hamster.
PMID 190868 · Acta physiologica Scandinavica · 1977 · DOI 10.1111/j.1748-1716.1977.tb10372.x
Authors: B Falck; C Hansson; B M Kennedy; E Rosengren
Abstract
Two glucuronidated catechol have been identified in a transplantable islet cell tumour of the golden hamster, i.e. dopamine-4-O-glucuronide and 3-methoxytyramine-4-O-glucuronide. L-dopa is rapidly metabolized in the tumour to one or both of these glucuronides. Incubation of tumour homogenates in the presence of beta-glucuronidase shows that dopamine-4-O-glucuronide is present in the tumour in extremely high concentrations.
Adenoma, Islet Cell; Animals; Catechols; Chromatography, Paper; Cricetinae; Dopamine; Glucuronates; Glucuronidase; Levodopa; Mass Spectrometry; Neoplasm Transplantation; Neoplasms, Experimental; Spectrometry, Fluorescence; Tyramine
Cite
B Falck; C Hansson; B M Kennedy; E Rosengren. Conjugated catechol derivatives in a transplantable islet cell tumour of the golden hamster. Acta physiologica Scandinavica (1977). PMID 190868. DOI 10.1111/j.1748-1716.1977.tb10372.x.