Stimulation of longitudinal bone growth by hypophyseal hormones in the hypophysectomized rat.
PMID 190839 · Acta endocrinologica · 1977 · DOI 10.1530/acta.0.0840485
Authors: K G Thorngren; L I Hansson
Abstract
The stimulating effect of different pituitary hormones on longitudinal bone growth was determined with tetracycline as intravital marker in hypophysectomized rats. Growth hormone was found to be the most effective growth stimulating pituitary hormone. At considerably higher doses, thyrotrophic hormone (TSH) and prolactin also showed growth stimulating pituitary hormone. At considerably higher doses, thyrotrophic hormone (TSH) and prolactin also showed growth stimulating activity. TSH exerts its effect via the production of thyroxine, whereas the growth stimulation by prolactin seems to be a direct effect of this hormone, similar to the effect of growth hormone. The LH, FSH, ACTH, MSH, vasopressin and oxytocin preparations did not stimulate longitudinal bone growth.
Adrenocorticotropic Hormone; Animals; Body Weight; Bone Development; Cartilage; Drug Synergism; Female; Follicle Stimulating Hormone; Growth Hormone; Hypophysectomy; Luteinizing Hormone; Melanocyte-Stimulating Hormones; Oxytocin; Pituitary Hormones; Prolactin; Rats; Stimulation, Chemical; Thyrotropin; Thyroxine; Tibia; Vasopressins
Cite
K G Thorngren; L I Hansson. Stimulation of longitudinal bone growth by hypophyseal hormones in the hypophysectomized rat. Acta endocrinologica (1977). PMID 190839. DOI 10.1530/acta.0.0840485.