[Liver transplantation with no-heatbeating donor supplied gaseous oxygen during cold preservation in pigs].
PMID 11856492 · Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2002
Authors: Zhongxue Fu; Stefan Saad; Manfred Nagelschmidt; Wenmiao Han
Abstract
To investigate the availability of liver transplantation with non-heart beating (60 min) donors supplied gaseous oxygen by hepatic vein in cold preservation period in pigs. Thirty-six pigs were randomly divided into three recipient groups and three donor groups (group A-15 min of warm ischaemia, group B-60 min of warm ischaemia and group C-60 min of warm ischaemia with gaseous oxygen by hepatic vein during cold preservation period). OTL was performed after four hours cold preservation. Postoperative 5 days survival rate of the liver metabolic, function and inflammatory reaction were observed. All animals in group A and C survived after reperfusion for 5 days, but animals in group B died within 3 hours postreperfusion. The damage of liver construction and function were found in group A and group B. There was no significant difference of the changes between group A and C. Gaseous oxygen persufflation during cold preservation has important protective and resuscitative effect for liver from long-time no-heart beating donors. It was possible to become a promising method for liver transplantation with no-hearbeating donors.
Animals; Cryopreservation; Heart Arrest; Hepatic Veins; Liver; Liver Function Tests; Liver Transplantation; Oxygen; Reperfusion; Reperfusion Injury; Superoxide Dismutase; Swine; Tissue Donors; Tissue Preservation
Cite
Zhongxue Fu; Stefan Saad; Manfred Nagelschmidt; Wenmiao Han. [Liver transplantation with no-heatbeating donor supplied gaseous oxygen during cold preservation in pigs]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (2002). PMID 11856492.