[Prevention and treatment of HBV reinfection following liver transplantation].
PMID 11856491 · Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2002
Authors: Guiyu Yuan; Yili Duan; Fengshui Wang; Shuren Liang; Limin Zhu
Abstract
To study the prevention and treatment of HBV reinfection after liver transplantation. Total 19 cases of chronic fulminant hepatitis B, the end-stage of liver cirrhosis and liver carcinoma complicated with HBV cirrhosis. Were performed liver transplantation and given anti-viral drugs pre and post transplantation. Famciclovir was administered in 4 cases, lamivudine in 13 cases and lamivudine+HBIG in 2 cases. The serum HBVM and liver biopsy immunohistochemistry were performed. Four cases given famciclovir developed reinfection. Serum HBsAg, HBeAg and HBV DNA were positive in 3 cases. Liver biopsy immunohistochemistry showed HBsAg and HBeAg phenotype. Classical viral hepatitis in 1 case occurred, three cases died. In the lamivudin group 7 cases showed positive for HBsAg, 2 cases positive for HBV DNA, 4 cases HBsAg or HBcAg phenotype. One case showed positive for serum anti-HBc the other negative for HBVM, and liver biopsy immunohistochemistry was negative too. These date suggest that anti-virus prevention and treatment in pre and post liver transplantation with HBV infected correlative disease is necessary, feasible and effective.
2-Aminopurine; Adult; Antiviral Agents; Biopsy; DNA, Viral; Drug Combinations; Famciclovir; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B e Antigens; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Postoperative Care; Preoperative Care; Recurrence
Cite
Guiyu Yuan; Yili Duan; Fengshui Wang; Shuren Liang; Limin Zhu. [Prevention and treatment of HBV reinfection following liver transplantation]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (2002). PMID 11856491.