Vascular progenitors: from biology to treatment.
PMID 11852257 · Trends in cardiovascular medicine · 2002 · DOI 10.1016/s1050-1738(01)00152-9
Authors: Aernout Luttun; Geert Carmeliet; Peter Carmeliet
Abstract
The identification of endothelial progenitor cells (EPCs) in the adult human has forced us to reconsider how new blood vessels grow in physiological and pathological conditions in the adult human. An important question in angiogenesis research is to what extent these progenitors functionally contribute to revascularization of ischemic tissues and and to what extent they can be used for therapeutic angiogenic cell transplantation. Even more challenging is the concept that hematopoietic and other bone-marrow-derived stem cells might be recruited in the context of ischemia to induce neovessel formation. This review discusses some of the recent insights and outstanding questions on EPCs, both from a biological and therapeutic perspective.
Adult; Animals; Cell Transplantation; Embryo, Mammalian; Embryo, Nonmammalian; Endothelium, Vascular; Extremities; Hematopoietic Stem Cells; Humans; Mice; Mice, Nude; Neovascularization, Physiologic; Rats; Rats, Nude; Zebrafish
Cite
Aernout Luttun; Geert Carmeliet; Peter Carmeliet. Vascular progenitors: from biology to treatment. Trends in cardiovascular medicine (2002). PMID 11852257. DOI 10.1016/s1050-1738(01)00152-9.