C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction.
PMID 10415744 · Annals of the New York Academy of Sciences · 1999 · DOI 10.1111/j.1749-6632.1999.tb07698.x
Authors: W V Giannobile
Abstract
C-telopeptides and related pyridinoline cross-links of bone Type I collagen are sensitive markers of bone resorption in osteolytic diseases such as osteoporosis and osteoarthritis. We have studied the release of C-telopeptide pyridinoline crosslinks of Type I collagen as measures of bone destruction in periodontal disease. Studies in preclinical animal models and humans have demonstrated the relationship between radiographic bone loss and crevicular fluid C-telopeptide levels. We have recently found that C-telopeptide levels correlate strongly with microbial pathogens associated with periodontitis and around endosseous dental implants. Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease.
Alveolar Bone Loss; Amino Acids; Animals; Biomarkers; Bone Resorption; Collagen; Collagen Type I; Humans; Osteoarthritis; Osteoporosis; Peptides; Periodontal Diseases
Cite
W V Giannobile. C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction. Annals of the New York Academy of Sciences (1999). PMID 10415744. DOI 10.1111/j.1749-6632.1999.tb07698.x.